EVALUATATION OF THE LEVEL OF VITAMIN C, VITAMIN E AND MALONDIALDEHYDE IN MALE SMOKERS AND NON SMOKERS.
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EVALUATATION OF THE LEVEL OF VITAMIN C, VITAMIN E AND
MALONDIALDEHYDE IN MALE SMOKERS AND NON SMOKERS.
BACKGROUND OF STUDY
Tobacco smoking is a
practice of burning tobacco and inhaling the smoke (consisting of gaseous
phases and particles). A more broad definition may include taking tobacco smoke
into the mouth, and then releasing it, as is done by some with tobacco pipes
and cigars. The practice may have begun as early as 5000-3000 BC (Nagarajet
al., 2014).Cigarette smoking is probably the most addictive and dependence
producing form of object-specific, self-administered gratification known to
man. According to present estimates, tobacco is responsible for causing more
than 5 million deaths every year (World Health Organization, 2008).
The harmful effects of cigarette smoking onhuman health have
been well documented.It has been known that cigarette smoke carriesaround 4000
chemicals including toxic metals,poisonous gases and free radicals (Schumacher
et al., 2009). Amongst theseconstituents, free radicals are considered to be
moredangerous as these owing to their unpaired electron
are highly reactive and can cause oxidative damageto
biomolecules and biomembranes (Senet al., 2010).
Smoking plays an important role in disturbing the antioxidant
balance. Normally blood contains a healthy complement of antioxidants that keep
oxidative damage to a minimum. Tobacco smoke contains abundant reactive oxygen
species and also activated neutrophils released due to smoking also add to the
pool of reactive oxygen species which deplete these antioxidant mechanisms
leading to tissue damage (Kumaret al., 2010).
Malondialdehyde is a organic compound with the formula CH2
(CHO). This reactive species occurs naturally and is a marker for oxidative
stress.
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